2,658 research outputs found
Weak pairwise correlations imply strongly correlated network states in a neural population
Biological networks have so many possible states that exhaustive sampling is
impossible. Successful analysis thus depends on simplifying hypotheses, but
experiments on many systems hint that complicated, higher order interactions
among large groups of elements play an important role. In the vertebrate
retina, we show that weak correlations between pairs of neurons coexist with
strongly collective behavior in the responses of ten or more neurons.
Surprisingly, we find that this collective behavior is described quantitatively
by models that capture the observed pairwise correlations but assume no higher
order interactions. These maximum entropy models are equivalent to Ising
models, and predict that larger networks are completely dominated by
correlation effects. This suggests that the neural code has associative or
error-correcting properties, and we provide preliminary evidence for such
behavior. As a first test for the generality of these ideas, we show that
similar results are obtained from networks of cultured cortical neurons.Comment: Full account of work presented at the conference on Computational and
Systems Neuroscience (COSYNE), 17-20 March 2005, in Salt Lake City, Utah
(http://cosyne.org
Superluminal motion of a relativistic jet in the neutron star merger GW170817
The binary neutron star merger GW170817 was accompanied by radiation across
the electromagnetic spectrum and localized to the galaxy NGC 4993 at a distance
of 41+/-3 Mpc. The radio and X-ray afterglows of GW170817 exhibited delayed
onset, a gradual rise in the emission with time as t^0.8, a peak at about 150
days post-merger, followed by a relatively rapid decline. To date, various
models have been proposed to explain the afterglow emission, including a
choked-jet cocoon and a successful-jet cocoon (a.k.a. structured jet). However,
the observational data have remained inconclusive as to whether GW170817
launched a successful relativistic jet. Here we show, through Very Long
Baseline Interferometry, that the compact radio source associated with GW170817
exhibits superluminal motion between two epochs at 75 and 230 days post-merger.
This measurement breaks the degeneracy between the models and indicates that,
while the early-time radio emission was powered by a wider-angle outflow
(cocoon), the late-time emission was most likely dominated by an energetic and
narrowly-collimated jet, with an opening angle of <5 degrees, and observed from
a viewing angle of about 20 degrees. The imaging of a collimated relativistic
outflow emerging from GW170817 adds substantial weight to the growing evidence
linking binary neutron star mergers and short gamma-ray bursts.Comment: 42 pages, 4 figures (main text), 2 figures (supplementary text), 2
tables. Referee and editor comments incorporate
Two-Fermion Bound States within the Bethe-Salpeter Approach
To solve the spinor-spinor Bethe-Salpeter equation in Euclidean space we
propose a novel method related to the use of hyperspherical harmonics. We
suggest an appropriate extension to form a new basis of spin-angular harmonics
that is suitable for a representation of the vertex functions. We present a
numerical algorithm to solve the Bethe-Salpeter equation and investigate in
detail the properties of the solution for the scalar, pseudoscalar and vector
meson exchange kernels including the stability of bound states. We also compare
our results to the non relativistic ones and to the results given by light
front dynamics.Comment: 32 pages, XIII Tables, 8 figure
Class II phosphoinositide 3-kinase C2 beta regulates a novel signaling pathway involved in breast cancer progression
It is now well established that the enzymes phosphoinositide 3-kinases (PI3Ks) have a key role in the development and progression of many cancer types and indeed PI3Ks inhibitors are currently being tested in clinical trials. Although eight distinct PI3K isoforms exist, grouped into three classes, most of the evidence currently available are focused on one specific isoform with very little known about the potential role of the other members of this family in cancer. Here we demonstrate that the class II enzyme PI3K-C2β is overexpressed in several human breast cancer cell lines and in human breast cancer specimens. Our data indicate that PI3K-C2β regulates breast cancer cell growth in vitro and in vivo and that PI3K-C2β expression in breast tissues is correlated with the proliferative status of the tumor. Specifically we show that downregulation of PI3K-C2β in breast cancer cell lines reduces colony formation, induces cell cycle arrest and inhibits tumor growth, in particular in an estrogen-dependent in vivo xenograft. Investigation of the mechanism of the PI3K-C2β-dependent regulation of cell cycle progression and cell growth revealed that PI3K-C2β regulates cyclin B1 protein levels through modulation of microRNA miR-449a levels. Our data further demonstrate that downregulation of PI3K-C2β inhibits breast cancer cell invasion in vitro and breast cancer metastasis in vivo. Consistent with this, PI3K-C2β is highly expressed in lymph-nodes metastases compared to matching primary tumors. These data demonstrate that PI3K-C2β plays a pivotal role in breast cancer progression and in metastasis development. Our data indicate that PI3K-C2β may represent a key molecular switch that regulates a rate-limiting step in breast tumor progression and therefore it may be targeted to limit breast cancer spread
The anomalous U(1) global symmetry and flavors from an SU(5) x SU(5) GUT in orbifold compactification
In string compactifications, frequently there appears the anomalous U(1)
gauge symmetry which belonged to E8E8 of the heterotic string. This
anomalous U(1) gauge boson obtains mass at the compactification scale, just
below GeV, by absorbing one pseudoscalar (corresponding to the
model-independent axion) from the second rank anti-symmetric tensor field
.
Below the compactification scale, there results a global symmetry U(1) whose charge is the original gauge U(1) charge. This is
the most natural global symmetry, realizing the "invisible" axion. This global
symmetry U(1) is suitable for a flavor symmetry. In the simplest
compactification model with the flipped SU(5) grand unification, we calculate
all the low energy parameters in terms of the vacuum expectation values of the
standard model singlets.Comment: 18 pages, 4 figur
Stimulus-dependent maximum entropy models of neural population codes
Neural populations encode information about their stimulus in a collective
fashion, by joint activity patterns of spiking and silence. A full account of
this mapping from stimulus to neural activity is given by the conditional
probability distribution over neural codewords given the sensory input. To be
able to infer a model for this distribution from large-scale neural recordings,
we introduce a stimulus-dependent maximum entropy (SDME) model---a minimal
extension of the canonical linear-nonlinear model of a single neuron, to a
pairwise-coupled neural population. The model is able to capture the
single-cell response properties as well as the correlations in neural spiking
due to shared stimulus and due to effective neuron-to-neuron connections. Here
we show that in a population of 100 retinal ganglion cells in the salamander
retina responding to temporal white-noise stimuli, dependencies between cells
play an important encoding role. As a result, the SDME model gives a more
accurate account of single cell responses and in particular outperforms
uncoupled models in reproducing the distributions of codewords emitted in
response to a stimulus. We show how the SDME model, in conjunction with static
maximum entropy models of population vocabulary, can be used to estimate
information-theoretic quantities like surprise and information transmission in
a neural population.Comment: 11 pages, 7 figure
MRI-based microrobotic system for the propulsion and navigation of ferromagnetic microcapsules
Brain Performance versus Phase Transitions
We here illustrate how a well-founded study of the brain may originate in assuming analogies with phase-transition phenomena. Analyzing to what extent a weak signal endures in noisy environments, we identify the underlying mechanisms, and it results a description of how the excitability associated to (non-equilibrium) phase changes and criticality optimizes the processing of the signal. Our setting is a network of integrate-and-fire nodes in which connections are heterogeneous with rapid time-varying intensities mimicking fatigue and potentiation. Emergence then becomes quite robust against wiring topology modification—in fact, we considered from a fully connected network to the Homo sapiens connectome—showing the essential role of synaptic flickering on computations. We also suggest how to experimentally disclose significant changes during actual brain operation.The authors acknowledge support from the Spanish Ministry of Economy and Competitiveness under the project FIS2013-43201-P
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Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
We present results from a semicoherent search for continuous gravitational
waves from the low-mass X-ray binary Scorpius X-1, using a hidden Markov model
(HMM) to track spin wandering. This search improves on previous HMM-based
searches of LIGO data by using an improved frequency domain matched filter, the
-statistic, and by analysing data from Advanced LIGO's second
observing run. In the frequency range searched, from to
, we find no evidence of gravitational radiation. At
, the most sensitive search frequency, we report an upper
limit on gravitational wave strain (at 95\% confidence) of when marginalising over source inclination angle. This is the
most sensitive search for Scorpius X-1, to date, that is specifically designed
to be robust in the presence of spin wandering
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